Anti-ErbB2 Monoclonal Antibody
產品名稱： Anti-ErbB2 Monoclonal Antibody
英文名稱： Anti-ErbB2 Monoclonal Antibody
產品編號： K000166M
產品價格： null
產品產地： 北京
品牌商標： Solarbio
更新時間： 2025-11-13T16:32:10
使用范圍： WB
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發區環科中路16號26幢3層301
- 郵編 :
- 所在區域 : 北京
- 電話 : 181****6239 點擊查看
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- 郵箱 : 3193328036@qq.com
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Anti-ErbB2 Monoclonal Antibody
品牌：solarbio | 貨號：K000166M?
| 宿主 | Mouse |
|---|---|
| 英文名稱 | Anti-ErbB2 Monoclonal Antibody |
| 別名 | CD340;HER-2;HER-2/neu;HER2;MLN19;NEU;NGL;TKR1 |
| 應用 | WB |
| 稀釋比例 | WB 1:1000. |
| 蛋白分子量 | 138kDa |
| Gene ID | 2064 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | Purified recombinant human ErbB2 protein fragments expressed in E.coli. |
| 性狀 | 液體 |
| Subcellular Locations | Cell membrane Cytoplasm Nucleus Nucleus Single-pass type I membrane protein perinuclear region |
| Swiss Prot | P04626 |
| 克隆號 | 5B6-A9-C8 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |