Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody
產品名稱： Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody
英文名稱： beta Catenin (phospho S33/37);beta Catenin (phospho Ser33/37);p-beta Catenin (S33/37);p-beta Catenin (Ser33/37);p-beta Catenin (phospho S33/37);beta-c
產品編號： K009589P
產品價格： null
產品產地： 北京
品牌商標：
更新時間： 2025-11-13T16:32:10
使用范圍： WB ELISA IHC-P IHC-F Flow-Cyt ICC IF
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發區環科中路16號26幢3層301
- 郵編 :
- 所在區域 : 北京
- 電話 : 181****6239 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 3193328036@qq.com
- 二維碼 : 點擊查看
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.