去整合素樣金屬蛋白酶2抗體
產(chǎn)品名稱： 去整合素樣金屬蛋白酶2抗體
英文名稱： ADAM2
產(chǎn)品編號： bs-5851R
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 北京
品牌商標： BIOSS
更新時間： 2025-11-13T16:50:54
使用范圍： WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,
北京索萊寶科技有限公司
- 聯(lián)系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經(jīng)濟技術開發(fā)區(qū)環(huán)科中路16號26幢3層301
- 郵編 :
- 所在區(qū)域 : 北京
- 電話 : 181****6239 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 3193328036@qq.com
- 二維碼 : 點擊查看
ADAM-2, also known as PH-30?and Fertilin-? was first described as a sperm-egg fusion protein from guinea pig. A member of the metalloproteinase family containing disintigrin-like domains (ADAMs), the function of ADAM-2 is still poorly understood. Unlike ADAM-1, ADAM-2 does not contain the canonical HExxHxxxxxH zinc metalloproteinase motif, and is not thought to be proteolytically active. Like the other ADAMs, ADAM-2 domain structure consists of a signal sequence followed by a propeptide domain, a metalloproteinase domain, a disintegrin domain cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. Three isoforms of ADAM-2 are reported to date, which differ in the beginning of the metalloproteinase domain and cysteine-rich domain. The sequences are coded from intronless genes. The longest ADAM-2 message encodes a protein of 735 amino acids, with a predicted mass of 82.5 kDa and a pI of 5.73. The 716 amino acid form of ADAM-2 has a deletion in the start of the metalloproteinase domain, relative to the longer form, and has a predicted mass of 80.2 kDa and pI of 5.75. The shorter form of 579 amino acids shared the deletion in the MP domain, and also has a deletion in the cystein-rich domain. Localized on the surface of sperm, the ADAM-2 isoforms are thought to form a heterodimer with ADAM-1 (fertilin-a), and facilitate sperm-egg fusion, although there is some controversy about the precise actions the proteins play. Integrin a6? on the egg surface is thought to dock with a QDECD motif in the disintegrin domain of ADAM-2, and there is some speculation that ADAM-1/ADAM-2 heterodimewr initiated ADAM-3 production on the cell surface.