【SAM-P8小鼠SAM-R1小鼠快速老化小鼠銷售】
產(chǎn)品名稱： 【SAM-P8小鼠SAM-R1小鼠快速老化小鼠銷售】
英文名稱： zhongke
產(chǎn)品編號： SAM-P8、SAM-R1
產(chǎn)品價格： 合格產(chǎn)品
產(chǎn)品產(chǎn)地： null
品牌商標(biāo)： null
更新時間： null
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- 聯(lián)系人 : 彭老師
- 地址 : 北京市海淀區(qū)復(fù)興路
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- 所在區(qū)域 : 北京
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SPF級SAM-P8小鼠SAM-P8mice快速老化小鼠銷售價格優(yōu)惠，SPF級SAM-R1小鼠SAM-P8mice快速老化小鼠銷售價格優(yōu)惠，保質(zhì)保量，提供質(zhì)量合格證，可送貨到實(shí)驗(yàn)室
STRAIN NAME:?Senescence accelerated mouse/prone8
TYPE:?Spontaneous mutation
BACKGROUND STRAIN:?AKR/J
COAT COLOR:?White (Albino)
ORIGIN:?In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION:?learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs