磷酸化磷脂酰肌醇激酶催化亞單位A抗體
產品名稱： 磷酸化磷脂酰肌醇激酶催化亞單位A抗體
英文名稱： phospho-PI3KCA(Tyr317)
產品編號： bs-5570R
產品價格： null
產品產地： 北京
品牌商標： BIOSS
更新時間： 2025-11-13T16:32:10
使用范圍： WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發區環科中路16號26幢3層301
- 郵編 :
- 所在區域 : 北京
- 電話 : 181****6239 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 3193328036@qq.com
- 二維碼 : 點擊查看
PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.