G蛋白偶聯(lián)受體激酶相互作用蛋白2抗體
產(chǎn)品名稱： G蛋白偶聯(lián)受體激酶相互作用蛋白2抗體
英文名稱： GIT2
產(chǎn)品編號： bs-13360R
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 北京
品牌商標(biāo)： BIOSS
更新時(shí)間： 2025-08-18T10:57:58
使用范圍： WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,
北京索萊寶科技有限公司
- 聯(lián)系人 : 索萊寶-龔思雨
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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).