?核受體靶點(diǎn)篩選
?目前發(fā)現(xiàn)48個(gè)成員,與代謝性疾病關(guān)系密切
?建立了以熒光素酶報(bào)告基因?yàn)橹鞯暮耸荏w篩選平臺(tái)
已建立的核受體列表
?
|
Nuclear?receptor?family |
Targets |
|
Thyroid hormone receptor |
TRα, TRβ |
|
Peroxisome proliferator-activated receptor |
LXRα, LXRβ, FXR, FXR-β |
|
Retinoic acid receptor |
RARα, RARβ, RARγ |
|
Liver X receptor-like |
?LXRα,?LXRβ |
|
3-Ketosteroid receptors |
GR,?MR, PR, AR |
|
Estrogen receptor |
Erα, Erβ |
?
Example:熒光素酶報(bào)告基因驗(yàn)證
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